Neonatal thromboembolism is rare and in most cases iatrogenic from indwelling central catheters, peripheral arterial lines, and umbilical lines and also numerous clinical conditions. It often requires urgent intervention to restore perfusion and to avoid morbidity and even mortality. Very few case reports of neonatal thrombosis after birth are described in the literature. We present the case of a full-term infant with respiratory distress syndrome, noted to have marked color change on right leg caused by disseminated intravascular coagulation at birth day. Doppler ultrasound of the leg demonstrated a thrombus in the right femoral and popliteal veins. He underwent right leg thrombectomy and anticoagulant therapy with poor recovery so that finally he had an operation for amputation. We present a case of venous thromboembolism caused by disseminated intravascular coagulation in neonate with respiratory distress syndrome.